Understanding Drug Release Data through Thermodynamic Analysis

Understanding Drug Release Data through Thermodynamic Analysis

Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters...

Understanding Kinetics of Drug Release from Ointments

X. Xu, M. Al-Ghabeish, Y. S. Krishnaiah, Z. Rahman, M. A. Khan U.S. Food and Drug Administration Purpose From a drug product quality perspective, in vitro release testing (IVRT) serves many different, yet crucial roles throughout the lifecycle of a drug product. Unfortunately, the maturity of IVRT methods for pharmaceutical ointments is considerably lacking and under-utilized as compared to con...

Thermodynamic analysis in fragment-based drug discovery

Thermodynamic analysis provides access to the determinants of binding affinity, enthalpy and entropy. In fragment-based drug discovery (FBDD), thermodynamic analysis provides a powerful tool to discriminate fragments based on their potential for successful optimization. The thermodynamic data generated by FBDD studies can in turn be used to better understand the forces that drive biomolecular i...

controlled drug release of methylphenidate through pelletization process

Understanding Normal and Atypical Operations through Analysis of Flight Data

Over the past several years, airlines have initiated or participated in a number of safety data programs. Each involves collection of voluntary safety reports or the monitoring of flight data. These initiatives grew from recognition that mitigating safety risks requires monitoring a variety of data streams – reports, observations, and flight data. They have spawned technologies within air carri...